Pharmaceutical Preparations · SIC 2834

Alto Neuroscience, Inc.

ANRO

Watch

Latest revenue

$6.6M

as of 2025-12-31

Latest net income

$-63.2M

as of 2025-12-31

Net margin

-957.7%

as of 2025-12-31

8.0
of 10

ActaClear Score

Strong
#83 of 528 in Pharmaceutical Preparations
+0.4 · 2d
Profitability·25%
6.2
Growth·15%
9.3
Value·20%
8.3
Quality·20%
8.8
Momentum·20%

Computed from 5 years of SEC fundamentals + latest market data, ranked within Pharmaceutical Preparations (528 peers). 10 = best in industry, 5 = median, 0 = worst. Refreshed Jun 7, 2026.

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Price · 5Y

-5.2% / yr 24.9 pts / yr vs S&P 500 11.8% total
Compare:

Live market

delayed ≤15 min
$18.18
Market cap
$638.2M
Enterprise value
$392.8M
P/E (trailing)
Forward P/E
P/B
2.62×
Dividend yield
0.0%
52-wk high
$28.44
52-wk low
$2.15
Beta
Shares out
35.1M

5-year trend

dashed bar = fiscal Q4 derived from 10-K annual − Q1 − Q2 − Q3 (SEC requires only three 10-Qs per year).

What this company does

AI

Item 1. Business. Overview We are a clinical-stage biopharmaceutical company with a mission to redefine psychiatry by leveraging neurobiology to develop personalized and highly effective treatment options. Through insights derived from our scalable and proprietary Precision Psychiatry Platform, or our Platform, we aim to discover brain-based biomarkers to better identify which patients are more likely to respond to our novel product candidates. Our current pipeline consists of seven clinical-stage assets addressing high-need therapeutic areas, including major depressive disorder, or MDD, bipolar depression, or BPD, treatment resistant depression, or TRD, schizophrenia, and Parkinson’s…

AI summary unavailable — showing raw filing excerpt

Generated from ANRO's filing dated 2026-03-16

Key risks

AI

Table of Contents Item 1A. Risk Factors. Investing in our common stock involves a high degree of risk. You should carefully consider the risks and uncertainties described below, together with all of the other information contained in this Annual Report, including our consolidated financial statements and their related notes included elsewhere in this Annual Report and the section titled “Management’s Discussion and Analysis of Financial Condition and Results of Operations” before making an investment decision. If any of the following risks actually occurs, our business, prospects, operating results, and financial condition could suffer materially, the trading price of our common stock could…

AI summary unavailable — showing raw filing excerpt

Generated from ANRO's filing dated 2026-03-16

Profitability

Operating margin

-1005.1%

29.7%

Net margin

-957.7%

38.0%

Return on equity

-41.8%

148.7%

Return on assets

-34.2%

1.0%

Leverage

Debt / equity

0.22×

106.3%

Long-term debt / equity

0.11×

174.6%

Debt / assets

18.0%

87.2%

Earnings tracker

QuarterRevenueYoYNet incomeYoYNet margin

Q1 2026

2026-03-31

$-26.2M-73.0%

Q4 2025

2025-12-31

$-16.2M-6.5%

Q3 2025

2025-09-30

$-14.2M+15.5%

Q2 2025

2025-06-30

$-17.7M-10.5%

Q1 2025

2025-03-31

$-15.2M-13.1%

Q4 2024

2024-12-31

$-15.2M

Q3 2024

2024-09-30

$-16.8M-83.6%

Q2 2024

2024-06-30

$-16.0M-85.0%

Year-over-year change vs the same fiscal quarter one year prior. Revenue + net income sourced from SEC 10-Q / 10-K filings — no analyst-consensus dependency.

Industry trend

Pharmaceutical Preparations · SIC 2834

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Insider activity

Insider buying

$0

Insider selling

$0

Net activity

+$0

Distinct insiders

0

Open-market trades over the last 365 days.

Recent transactions

DateInsiderTypeSharesPriceValue

Source: SEC Form 4 filings. Officers, directors, and 10%+ owners must disclose share transactions within two business days. RSU grants and tax-withholding rows are excluded by default — compensation activity is not a trading signal.

Who owns ANRO

Institutional value

$90.9M

Total shares held

4.1M

Distinct holders

43

-55 vs prior

As of

2026-03-31

Prior: 2025-12-31

Filers with $100M+ AUM disclose holdings 45 days after quarter end.

Top institutional holders

#ManagerSharesValueQoQ changeAction
1VANGUARD CAPITAL MANAGEMENT LLC1.2M$27.1MNew
2FRANKLIN RESOURCES INC1.1M$24.8M-17.7K (-1.6%)Trimmed
3BlackRock, Inc.666.2K$15.0M+58.3K (+9.6%)Added
4JENNISON ASSOCIATES LLC386.4K$8.7MNew
5VANGUARD FIDUCIARY TRUST CO165.3K$3.7MNew
6STIFEL FINANCIAL CORP86.3K$1.9M-829 (-1.0%)Trimmed
7TD ASSET MANAGEMENT INC43.8K$984.6KNew
8Hudson Bay Capital Management LP43.8K$983.8K+9.0K (+25.8%)Added
9AdvisorShares Investments LLC41.0K$922.2K-3.1K (-6.9%)Trimmed
10DIMENSIONAL FUND ADVISORS LP39.3K$884.0K+8.1K (+26.1%)Added
11JANE STREET GROUP, LLC30.1K$675.7K-164.0K (-84.5%)Trimmed
12Allianz Asset Management GmbH28.5K$640.7K-14.5K (-33.7%)Trimmed
13ALPS ADVISORS INC25.3K$568.5K-217 (-0.9%)Trimmed
14Y-Intercept (Hong Kong) Ltd23.9K$538.3KNew
15UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO22.2K$498.5K+0 (+0.0%)No change
16LANDSCAPE CAPITAL MANAGEMENT, L.L.C.18.1K$406.5KNew
17UBS Group AG17.3K$387.8K-1.2K (-6.7%)Trimmed
18Revisor Wealth Management LLC17.1K$385.1KNew
19SCS Capital Management LLC16.8K$378.6K-16.5K (-49.6%)Trimmed
20Clearstead Advisors, LLC13.3K$299.3KNew

Source: SEC Form 13F-HR. Positions aggregated across sub-managers within each firm. Options (puts/calls) excluded — common stock only.

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