Biological Products, (No Diagnostic Substances) · SIC 2836

Apogee Therapeutics, Inc.

APGE

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Latest revenue

as of

Latest net income

as of

Net margin

as of

Price · 5Y

+59.9% / yr 46.2 pts / yr vs S&P 500 282.3% total
Compare:

Live market

delayed ≤15 min
$81.16
1.54%
Market cap
$6.08B
Enterprise value
$6.08B
P/E (trailing)
Forward P/E
P/B
Dividend yield
0.0%
52-wk high
$95.31
52-wk low
$34.34
Beta
Shares out
74.9M

5-year trend

What this company does

AI

Item 1. Business Overview We are a clinical stage biotechnology company advancing optimized, novel biologics with the potential for differentiated efficacy and dosing in the largest inflammatory and immunology (“I&I”) markets, including for the treatment of atopic dermatitis (“AD”), asthma, eosinophilic esophagitis (“EoE”), chronic obstructive pulmonary disease (“COPD”), and other I&I indications. Our antibody programs are designed to overcome limitations of existing therapies by targeting well-established mechanisms of action and incorporating advanced antibody engineering to optimize half-life and other properties. Our pipeline comprises multiple antibody programs being developed…

AI summary unavailable — showing raw filing excerpt

Generated from APGE's filing dated 2026-03-02

Key risks

AI

Item 1A. Risk Factors Investing in our common stock involves a high degree of risk. Before you decide to invest in our common stock, you should consider carefully the risks described below, together with the other information contained in this Annual Report, including “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and our audited consolidated financial statements and related notes. We believe the risks described below are the risks that are material to us as of the date of this Annual Report. Some of the factors, events and contingencies discussed below may have occurred in the past, but the disclosures below are not representations as to whether or…

AI summary unavailable — showing raw filing excerpt

Generated from APGE's filing dated 2026-03-02

Profitability

Return on assets

-27.3%

13.0%

Earnings tracker

QuarterRevenueYoYNet incomeYoYNet margin

Q1 2026

2026-03-31

$-74.1M-33.9%

Q4 2025

2025-12-31

$-69.4M-3.2%

Q3 2025

2025-09-30

$-65.0M-32.6%

Q2 2025

2025-06-30

$-66.1M-95.5%

Q1 2025

2025-03-31

$-55.3M-72.4%

Q4 2024

2024-12-31

$-67.2M

Q3 2024

2024-09-30

$-49.0M-135.2%

Q2 2024

2024-06-30

$-33.8M-79.1%

Year-over-year change vs the same fiscal quarter one year prior. Revenue + net income sourced from SEC 10-Q / 10-K filings — no analyst-consensus dependency.

Industry trend

Biological Products, (No Diagnostic Substances) · SIC 2836

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Insider activity

Insider buying

$15.0M

Insider selling

$154.6M

Net activity

−$139.6M

Distinct insiders

5

Open-market trades over the last 365 days.

Recent transactions

DateInsiderTypeSharesPriceValue
2026-05-13

Michael Thomas Henderson

Chief Executive Officer

Sale18,659$82.05$1.5M
2026-05-13

Michael Thomas Henderson

Chief Executive Officer

Sale1,341$82.58$110.7K
2026-05-06

Carl Dambkowski

Chief Medical Officer

Sale3,700$83.92$310.5K
2026-05-06

Carl Dambkowski

Chief Medical Officer

Sale1,800$84.60$152.3K
2026-05-01

Jane Henderson

Chief Financial Officer

Sale811$81.02$65.7K
2026-05-01

Jane Henderson

Chief Financial Officer

Sale900$82.60$74.3K
2026-05-01

Jane Henderson

Chief Financial Officer

Sale289$83.16$24.0K
2026-04-16

Jane Henderson

Chief Financial Officer

Sale2,000$90.00$180.0K
2026-04-08

Michael Thomas Henderson

Chief Executive Officer

Sale17,800$82.48$1.5M
2026-04-08

Michael Thomas Henderson

Chief Executive Officer

Sale2,000$83.26$166.5K
2026-04-08

Michael Thomas Henderson

Chief Executive Officer

Sale200$85.00$17.0K
2026-04-01

Carl Dambkowski

Chief Medical Officer

Sale2,698$84.31$227.5K
2026-04-01

Carl Dambkowski

Chief Medical Officer

Sale2,702$85.33$230.6K
2026-04-01

Carl Dambkowski

Chief Medical Officer

Sale100$85.89$8.6K
2026-04-01

Jane Henderson

Chief Financial Officer

Sale900$84.46$76.0K
2026-04-01

Jane Henderson

Chief Financial Officer

Sale1,100$85.46$94.0K
2026-03-25

Jane Henderson

Chief Financial Officer

Sale2,000$85.00$170.0K
2026-03-11

Michael Thomas Henderson

Chief Executive Officer

Sale8,363$74.29$621.3K
2026-03-11

Michael Thomas Henderson

Chief Executive Officer

Sale8,219$74.83$615.0K
2026-03-11

Michael Thomas Henderson

Chief Executive Officer

Sale3,418$75.86$259.3K
2026-03-04

Carl Dambkowski

Chief Medical Officer

Sale3,225$70.33$226.8K
2026-03-04

Carl Dambkowski

Chief Medical Officer

Sale2,075$71.98$149.4K
2026-03-04

Carl Dambkowski

Chief Medical Officer

Sale200$73.26$14.7K
2026-03-02

Jane Henderson

Chief Financial Officer

Sale300$68.27$20.5K
2026-03-02

Jane Henderson

Chief Financial Officer

Sale300$69.43$20.8K
2026-03-02

Jane Henderson

Chief Financial Officer

Sale994$70.45$70.0K
2026-03-02

Jane Henderson

Chief Financial Officer

Sale406$71.66$29.1K
2026-02-11

Michael Thomas Henderson

Chief Executive Officer

Sale11,494$62.96$723.7K
2026-02-11

Michael Thomas Henderson

Chief Executive Officer

Sale7,551$63.73$481.2K
2026-02-11

Michael Thomas Henderson

Chief Executive Officer

Sale955$64.99$62.1K

Source: SEC Form 4 filings. Officers, directors, and 10%+ owners must disclose share transactions within two business days. RSU grants and tax-withholding rows are excluded by default — compensation activity is not a trading signal.

Who owns APGE

Institutional value

$1.25B

Total shares held

15.0M

Distinct holders

108

-99 vs prior

As of

2026-03-31

Prior: 2025-12-31

Filers with $100M+ AUM disclose holdings 45 days after quarter end.

Top institutional holders

#ManagerSharesValueQoQ changeAction
1BlackRock, Inc.4.1M$343.9M+301.7K (+8.0%)Added
2VANGUARD CAPITAL MANAGEMENT LLC2.5M$210.6MNew
3UBS Group AG1.1M$96.3M+169.5K (+17.4%)Added
4JPMORGAN CHASE & CO1.1M$87.4M-262.6K (-19.1%)Trimmed
5JENNISON ASSOCIATES LLC585.0K$49.2M+6.4K (+1.1%)Added
6Remedium Capital Partners, LLC583.6K$49.1M+0 (+0.0%)No change
7FEDERATED HERMES, INC.442.7K$37.3M+314.8K (+246.1%)Added
8FRANKLIN RESOURCES INC405.5K$34.1M-45.5K (-10.1%)Trimmed
9VANGUARD PORTFOLIO MANAGEMENT LLC396.3K$33.4MNew
10VANGUARD FIDUCIARY TRUST CO369.0K$31.1MNew
11Capital World Investors348.7K$29.3M+221.1K (+173.2%)Added
12Pictet Asset Management Holding SA261.1K$22.0M-51.8K (-16.6%)Trimmed
13Candriam S.C.A.223.5K$18.8M-159.1K (-41.6%)Trimmed
14BNP PARIBAS FINANCIAL MARKETS220.1K$18.5M+210.1K (+2108.7%)Added
15TD ASSET MANAGEMENT INC184.8K$15.6M+55.5K (+42.9%)Added
16abrdn plc143.4K$12.1M+107.3K (+297.1%)Added
17Nuveen, LLC128.1K$10.8M+7.1K (+5.8%)Added
18Universal- Beteiligungs- und Servicegesellschaft mbH128.0K$10.8M+386 (+0.3%)Added
19Bank of New York Mellon Corp126.8K$10.7M+8.7K (+7.3%)Added
20KENNEDY CAPITAL MANAGEMENT LLC122.7K$10.3M-2.3K (-1.8%)Trimmed

Source: SEC Form 13F-HR. Positions aggregated across sub-managers within each firm. Options (puts/calls) excluded — common stock only.

Top questions investors are asking

Coming once APGE's latest filing finishes processing.