Medicinal Chemicals & Botanical Products · SIC 2833

Definium Therapeutics, Inc.

DFTX

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Latest revenue

as of

Latest net income

as of

Net margin

as of

Price · 5Y

+22.5% / yr 8.7 pts / yr vs S&P 500 118.5% total
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Live market

delayed ≤15 min
$22.50
0.66%
Market cap
$2.45B
Enterprise value
$2.45B
P/E (trailing)
Forward P/E
P/B
Dividend yield
0.0%
52-wk high
$26.25
52-wk low
$6.34
Beta
Shares out
109.1M

5-year trend

What this company does

AI

Item 1. Business. Overview We are a late-stage clinical biopharmaceutical company developing novel product candidates to treat brain health disorders. Our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale. We are developing a pipeline of innovative product candidates targeting neurotransmitter pathways that play key roles in brain health disorders. This specifically includes pharmaceutically optimized product candidates derived from the psychedelic and empathogen drug classes including DT120 (previously referred to as MM120), and DT402 (previously referred to as MM402), our…

AI summary unavailable — showing raw filing excerpt

Generated from DFTX's filing dated 2026-02-26

Key risks

AI

Item 1A. Risk Factors. The following information sets forth risk factors that could cause our actual results to differ materially from those contained in forward-looking statements we have made in this Annual Report and those we may make from time to time. You should carefully consider the risks described below, as well as the other information in this Annual Report, including our financial statements and related notes and the section titled “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” and in our other public filings in evaluating our business. The occurrence of any of the events or developments described below could harm our business, financial…

AI summary unavailable — showing raw filing excerpt

Generated from DFTX's filing dated 2026-02-26

Profitability

Operating margin

-2012.6%

54.6%

Net margin

-2052.6%

46.0%

Return on equity

-55.3%

22.9%

Return on assets

-41.8%

16.1%

Leverage

Debt / equity

0.32×

29.0%

Long-term debt / equity

0.12×

34.9%

Debt / assets

24.5%

21.9%

Earnings tracker

QuarterRevenueYoYNet incomeYoYNet margin

Q1 2026

2026-03-31

$-77.1M-230.2%

Q4 2025

2025-12-31

$-50.4M-45.2%

Q3 2025

2025-09-30

$-67.3M-391.6%

Q2 2025

2025-06-30

$-42.7M-630.2%

Q1 2025

2025-03-31

$-23.3M+57.1%

Q4 2024

2024-12-31

$-34.7M

Q3 2024

2024-09-30

$-13.7M+23.7%

Q2 2024

2024-06-30

$-5.9M+79.9%

Year-over-year change vs the same fiscal quarter one year prior. Revenue + net income sourced from SEC 10-Q / 10-K filings — no analyst-consensus dependency.

Industry trend

Medicinal Chemicals & Botanical Products · SIC 2833

No data yet for industry average

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Insider activity

Insider buying

$0

Insider selling

$2.1M

Net activity

−$2.1M

Distinct insiders

3

Open-market trades over the last 365 days.

Recent transactions

DateInsiderTypeSharesPriceValue
2026-03-25

Daniel Karlin

Chief Medical Officer

Sale8,018$18.47$148.1K
2026-03-25

Mark Sullivan

Chief Legal Officer

Sale10,702$18.47$197.7K
2026-03-25

Robert Barrow

Chief Executive Officer

Sale24,431$18.47$451.2K
2025-12-26

Daniel Karlin

Chief Medical Officer

Sale5,600$13.15$73.6K
2025-12-26

Robert Barrow

Chief Executive Officer

Sale25,791$13.15$339.1K
2025-12-26

Mark Sullivan

Chief Legal Officer

Sale11,276$13.15$148.2K
2025-09-25

Mark Sullivan

Chief Legal Officer

Sale11,278$9.77$110.2K
2025-09-25

Robert Barrow

Chief Executive Officer

Sale25,797$9.77$252.0K
2025-09-25

Daniel Karlin

Chief Medical Officer

Sale7,704$9.77$75.3K
2025-06-25

Mark Sullivan

Chief Legal Officer

Sale11,491$6.80$78.1K
2025-06-25

Daniel Karlin

Chief Medical Officer

Sale7,848$6.80$53.4K
2025-06-25

Robert Barrow

Chief Executive Officer

Sale26,491$6.80$180.1K

Source: SEC Form 4 filings. Officers, directors, and 10%+ owners must disclose share transactions within two business days. RSU grants and tax-withholding rows are excluded by default — compensation activity is not a trading signal.

Who owns DFTX

Institutional value

$353.8M

Total shares held

18.8M

Distinct holders

134

+126 vs prior

As of

2026-03-31

Prior: 2025-12-31

Filers with $100M+ AUM disclose holdings 45 days after quarter end.

Top institutional holders

#ManagerSharesValueQoQ changeAction
1BlackRock, Inc.8.5M$160.3MNew
2Candriam S.C.A.1.3M$24.4MNew
3VANGUARD CAPITAL MANAGEMENT LLC1.1M$20.7MNew
4VANGUARD PORTFOLIO MANAGEMENT LLC872.7K$16.5MNew
5Bank of New York Mellon Corp752.9K$14.2MNew
6Nuveen, LLC698.1K$13.2MNew
7VANGUARD FIDUCIARY TRUST CO575.9K$10.9MNew
8Ensign Peak Advisors, Inc546.8K$10.3M+284.8K (+108.7%)Added
9UBS Group AG494.0K$9.3MNew
10DEUTSCHE BANK AG\411.8K$7.8MNew
11BIT Capital GmbH277.5K$5.2MNew
12JANE STREET GROUP, LLC260.2K$4.9MNew
13JPMORGAN CHASE & CO264.5K$4.6MNew
14ROYCE & ASSOCIATES LP234.1K$4.4MNew
15SEVEN GRAND MANAGERS, LLC225.0K$4.3MNew
16Swiss National Bank158.4K$3.0MNew
17RHUMBLINE ADVISERS120.0K$2.3MNew
18Russell Investments Group, Ltd.119.5K$2.3MNew
19AdvisorShares Investments LLC91.3K$1.7MNew
20Invesco Ltd.88.1K$1.7MNew

Source: SEC Form 13F-HR. Positions aggregated across sub-managers within each firm. Options (puts/calls) excluded — common stock only.

Top questions investors are asking

Coming once DFTX's latest filing finishes processing.