Pharmaceutical Preparations · SIC 2834

Stoke Therapeutics, Inc.

STOK

Watch

Latest revenue

$6.2M

as of 2026-03-31

Latest net income

$-50.0M

as of 2026-03-31

Net margin

-802.7%

as of 2026-03-31

Price · 5Y

-5.9% / yr 19.6 pts / yr vs S&P 500 26.0% total
Compare:

Live market

delayed ≤15 min
$29.34
1.11%
Market cap
$1.83B
Enterprise value
$1.83B
P/E (trailing)
Forward P/E
P/B
Dividend yield
0.0%
52-wk high
$40.22
52-wk low
$9.09
Beta
Shares out
62.3M

5-year trend

What this company does

AI

Item 1. Business. Overview We are a late-stage clinical company dedicated to addressing the underlying causes of severe diseases by upregulating protein expression with RNA-based medicines. Using our proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, we are developing antisense oligonucleotides (“ASOs”) to selectively restore protein levels. Our first investigational, new medicine in development, zorevunersen (STK-001), is a potential disease modifying medicine that is in late-stage clinical testing for the treatment of Dravet syndrome, a severe and progressive genetic epilepsy. Dravet syndrome is characterized by frequent, prolonged and refractory seizures beginning…

AI summary unavailable — showing raw filing excerpt

Generated from STOK's filing dated 2026-03-16

Key risks

AI

Item 1A. Risk Factors. Investing in our common stock involves a high degree of risk. Before making your decision to invest in shares of our common stock, you should carefully consider the risks described below, together with the other information contained in this annual report, including our consolidated financial statements and the related notes and “Management’s Discussion and Analysis of Financial Condition and Results of Operations”. The risks and uncertainties described below are not the only ones we face. Additional risks and uncertainties that we are unaware of, or that we currently believe are not material, may also become important factors that affect us. We cannot assure you that…

AI summary unavailable — showing raw filing excerpt

Generated from STOK's filing dated 2026-03-16

Profitability

Operating margin

-11.2%

96.0%

Net margin

-3.7%

98.5%

Return on equity

-2.0%

95.0%

Return on assets

-1.6%

95.0%

Leverage

Debt / equity

0.19×

0.8%

Debt / assets

15.8%

0.7%

Earnings tracker

QuarterRevenueYoYNet incomeYoYNet margin

Q1 2026

2026-03-31

$6.2M-96.1%$-50.0M-144.3%-802.7%

Q4 2025

2025-12-31

$1.4M-93.8%$-57.9M-452.7%-4132.2%

Q3 2025

2025-09-30

$10.6M+117.2%$-38.3M-45.1%-360.7%

Q2 2025

2025-06-30

$13.8M+186.0%$-23.5M+8.6%-170.0%

Q1 2025

2025-03-31

$158.6M+3661.1%$112.9M+528.0%71.2%

Q4 2024

2024-12-31

$22.6M$-10.5M-46.4%

Q3 2024

2024-09-30

$4.9M+47.9%$-26.4M-7.7%-540.0%

Q2 2024

2024-06-30

$4.8M+294.7%$-25.7M+16.2%-531.9%

Year-over-year change vs the same fiscal quarter one year prior. Revenue + net income sourced from SEC 10-Q / 10-K filings — no analyst-consensus dependency.

Industry trend

Pharmaceutical Preparations · SIC 2834

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Insider activity

Insider buying

$0

Insider selling

$42.8M

Net activity

−$42.8M

Distinct insiders

9

Open-market trades over the last 365 days.

Recent transactions

DateInsiderTypeSharesPriceValue
2026-05-01

Barry Ticho

CHIEF MEDICAL OFFICER

Sale2,243$32.79$73.5K
2026-04-01

Barry Ticho

CHIEF MEDICAL OFFICER

Sale1,838$32.66$60.0K
2026-03-20

Jonathan Allan

GENERAL COUNSEL & CORP SEC

Sale8,692$33.64$292.4K
2026-03-20

Jonathan Allan

GENERAL COUNSEL & CORP SEC

Sale601$34.41$20.7K
2026-03-19

Barry Ticho

CHIEF MEDICAL OFFICER

Sale1,461$29.99$43.8K
2026-03-18

Barry Ticho

CHIEF MEDICAL OFFICER

Sale6,100$31.28$190.8K
2026-03-18

Barry Ticho

CHIEF MEDICAL OFFICER

Sale483$31.79$15.4K
2026-03-18

Barry Ticho

CHIEF MEDICAL OFFICER

Sale103$32.85$3.4K
2026-03-18

Thomas Leggett

Chief Financial Officer

Sale2,173$31.28$68.0K
2026-03-18

Thomas Leggett

Chief Financial Officer

Sale172$31.79$5.5K
2026-03-18

Thomas Leggett

Chief Financial Officer

Sale37$32.85$1.2K
2026-03-18

Jason Hoitt

Chief Patient Officer

Sale1,762$31.28$55.1K
2026-03-18

Jason Hoitt

Chief Patient Officer

Sale139$31.79$4.4K
2026-03-18

Jason Hoitt

Chief Patient Officer

Sale30$32.85$986
2026-03-18

Jonathan Allan

GENERAL COUNSEL & CORP SEC

Sale4,222$31.28$132.1K
2026-03-18

Jonathan Allan

GENERAL COUNSEL & CORP SEC

Sale334$31.79$10.6K
2026-03-18

Jonathan Allan

GENERAL COUNSEL & CORP SEC

Sale72$32.85$2.4K
2026-03-17

Barry Ticho

CHIEF MEDICAL OFFICER

Sale3,577$32.74$117.1K
2026-03-17

Barry Ticho

CHIEF MEDICAL OFFICER

Sale2,587$33.38$86.3K
2026-03-17

Thomas Leggett

Chief Financial Officer

Sale1,274$32.74$41.7K
2026-03-17

Thomas Leggett

Chief Financial Officer

Sale922$33.38$30.8K
2026-03-17

Jason Hoitt

Chief Patient Officer

Sale1,033$32.74$33.8K
2026-03-17

Jason Hoitt

Chief Patient Officer

Sale748$33.38$25.0K
2026-03-17

Jonathan Allan

GENERAL COUNSEL & CORP SEC

Sale2,476$32.74$81.1K
2026-03-17

Jonathan Allan

GENERAL COUNSEL & CORP SEC

Sale1,791$33.38$59.8K
2026-03-13

LEVIN ARTHUR A

Director

Sale605$36.80$22.3K

Source: SEC Form 4 filings. Officers, directors, and 10%+ owners must disclose share transactions within two business days. RSU grants and tax-withholding rows are excluded by default — compensation activity is not a trading signal.

Who owns STOK

Institutional value

$638.6M

Total shares held

19.7M

Distinct holders

98

-86 vs prior

As of

2026-03-31

Prior: 2025-12-31

Filers with $100M+ AUM disclose holdings 45 days after quarter end.

Top institutional holders

#ManagerSharesValueQoQ changeAction
1BlackRock, Inc.5.4M$175.4M+173.2K (+3.3%)Added
2Lynx1 Capital Management LP4.8M$155.1M-641.0K (-11.9%)Trimmed
3VANGUARD CAPITAL MANAGEMENT LLC2.4M$76.7MNew
4DIMENSIONAL FUND ADVISORS LP989.9K$32.2M+162.8K (+19.7%)Added
5Assenagon Asset Management S.A.907.0K$29.5M-320.7K (-26.1%)Trimmed
6BAILLIE GIFFORD & CO575.2K$18.7M+328.3K (+133.0%)Added
7Candriam S.C.A.502.0K$16.3M-391.4K (-43.8%)Trimmed
8VANGUARD PORTFOLIO MANAGEMENT LLC462.7K$15.1MNew
9Erste Asset Management GmbH446.0K$14.2M+50.0K (+12.6%)Added
10VANGUARD FIDUCIARY TRUST CO356.9K$11.6MNew
11Artisan Partners Limited Partnership315.5K$10.3MNew
12JPMORGAN CHASE & CO265.5K$8.4M-12.5K (-4.5%)Trimmed
13FIRST TRUST ADVISORS LP163.5K$5.3M+780 (+0.5%)Added
14UBS Group AG158.3K$5.2M-11.4K (-6.7%)Trimmed
15Invesco Ltd.150.0K$4.9M-109.5K (-42.2%)Trimmed
16Bank of New York Mellon Corp143.4K$4.7M+2.6K (+1.9%)Added
17FRANKLIN RESOURCES INC142.8K$4.6M+10.6K (+8.0%)Added
18Nuveen, LLC108.6K$3.5M+4.4K (+4.2%)Added
19HUSSMAN STRATEGIC ADVISORS, INC.84.0K$2.7M+21.0K (+33.3%)Added
20Swiss National Bank79.1K$2.6M+3.4K (+4.5%)Added

Source: SEC Form 13F-HR. Positions aggregated across sub-managers within each firm. Options (puts/calls) excluded — common stock only.

Top questions investors are asking

Coming once STOK's latest filing finishes processing.